What internal standard and external standard

Question

Accepted Answer

Internal and external standards are used in quality control to ensure accurate and reliable measurements.

Internal standard is a substance that is added to the sample being analyzed, which is used as a reference to measure the analyte of interest.
External standard is a separate sample with a known concentration of the analyte, which is used to calibrate the instrument and validate the accuracy of the measurements.
Internal standards help correct for variations in sample preparation and instrument response, improving the accuracy and precision of the measurements.
External standards provide a reference point for comparing the measurements and ensuring the instrument is properly calibrated.
For example, in pharmaceutical analysis, an internal standard like deuterated compound may be added to the sample to compensate for losses during sample preparation.
An external standard may be a certified reference material with a known concentration of the analyte, which is used to validate the accuracy of the instrument's measurements.

Accepted Answer

The internal standard used needs to provide a signal that is similar to the analyte signal in most ways but sufficiently different so that the two signals are readily distinguishable by the instrument.

Accepted Answer

The internal standard used needs to provide a signal that is similar to the analyte signal in most ways but sufficiently different so that the two signals are readily distinguishable by the instrument.

What internal standard and external standard

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