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Digi Career Interview Questions and Answers

Updated 30 Jan 2025
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Q1. What is the difference between adverse reaction and adverse drug reaction

Ans.

Adverse reaction is a broader term that includes any unexpected or harmful response to a substance, while adverse drug reaction specifically refers to reactions caused by medications.

  • Adverse reaction can be caused by various factors such as food, environmental factors, or medical procedures, while adverse drug reaction is specifically caused by medications.

  • Adverse drug reactions are more predictable and can be classified into different types such as allergic reactions, side e...read more

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Q2. What is Pharmacokinetics and pharmacodynamics

Ans.

Pharmacokinetics is the study of how drugs move through the body, while pharmacodynamics is the study of how drugs interact with the body to produce their effects.

  • Pharmacokinetics focuses on drug absorption, distribution, metabolism, and excretion in the body

  • Pharmacodynamics examines how drugs interact with receptors to produce their therapeutic or toxic effects

  • Understanding both pharmacokinetics and pharmacodynamics is crucial in determining the appropriate dosage and treatm...read more

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Q3. Coding and decoding strands of DNA and RNA

Ans.

Coding and decoding strands of DNA and RNA involves translating the genetic information into proteins.

  • DNA is transcribed into RNA, which is then translated into proteins

  • The genetic code consists of codons, each representing an amino acid

  • Mutations can lead to changes in the protein sequence

  • Examples: Transcription of DNA to mRNA, translation of mRNA to protein

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Q4. What is Lock and key mechanism

Ans.

Lock and key mechanism is a concept in biochemistry where a specific enzyme fits perfectly with a specific substrate, similar to a lock and key.

  • Enzymes act as keys that fit into specific substrates like locks

  • The specificity of the interaction ensures that only the correct substrate can bind to the enzyme

  • This mechanism is crucial for various biological processes such as digestion and metabolism

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Q5. IUPAC names for few molecules

Ans.

IUPAC names for few molecules

  • IUPAC names are systematic names given to molecules based on their structure

  • Examples include ethane (C2H6), methanol (CH3OH), and butanoic acid (C4H8O2)

  • IUPAC names follow a set of rules to ensure consistency and clarity in naming

  • They often include prefixes and suffixes to indicate functional groups and substituents

  • Knowing IUPAC names is important for communication in the scientific community

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Q6. What is ADME, PK, PD

Ans.

ADME stands for Absorption, Distribution, Metabolism, and Excretion. PK is Pharmacokinetics and PD is Pharmacodynamics.

  • ADME refers to the processes that a drug undergoes in the body - absorption, distribution, metabolism, and excretion.

  • PK involves the study of how the body affects a drug, including its absorption, distribution, metabolism, and excretion.

  • PD focuses on how a drug affects the body, including its mechanism of action and therapeutic effects.

  • Understanding ADME, PK,...read more

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Q7. Phases of clinical trial

Ans.

Phases of clinical trial include Phase 0, Phase I, Phase II, Phase III, and Phase IV.

  • Phase 0: Exploratory study involving very limited human exposure to the drug.

  • Phase I: Small group of healthy volunteers to determine safety and dosage.

  • Phase II: Larger group to further evaluate safety and efficacy.

  • Phase III: Large-scale study to confirm effectiveness, monitor side effects, and compare to existing treatments.

  • Phase IV: Post-marketing surveillance to monitor long-term effects an...read more

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