What is wet and dry granulation?

Question

Accepted Answer

Wet and dry granulation are two methods of forming granules from powder materials.

Wet granulation involves adding a liquid binder to the powder mixture, which is then agitated and dried to form granules.
Dry granulation involves compacting the powder mixture without the use of a liquid binder, using a roller compactor or tablet press.
Wet granulation is often used for materials that are difficult to compress, while dry granulation is preferred for materials that are sensitive to moisture or heat.
Examples of wet granulation include the production of tablets and capsules, while dry granulation is commonly used in the manufacture of controlled-release formulations.
Both methods have advantages and disadvantages, and the choice of which to use depends on the specific properties of the materials being processed.

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