How you going to determine the solubility for dissolution and sink condition?

Question

Accepted Answer

Solubility for dissolution and sink condition can be determined by conducting solubility studies and using appropriate sink conditions.

Conduct solubility studies using various solvents and methods such as shake-flask method or UV spectroscopy.
Ensure sink conditions are maintained by using a large volume of dissolution medium compared to the amount of drug being dissolved.
Monitor the concentration of the drug over time to determine the solubility profile.
Calculate the solubility using mathematical models such as the Noyes-Whitney equation.
Example: Conducting a solubility study of a drug in different pH buffers to determine its solubility profile.

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