20+ Centrient Pharmaceuticals Interview Questions and Answers

High pressure problem in chiller compressor

• High pressure in chiller compressor can be caused by various factors such as dirty condenser coils, refrigerant leaks, or a malfunctioning expansion valve.

• Excessive high pressure can lead to compressor overheating, reduced cooling capacity, and potential damage to the chiller system.

• Regular maintenance and monitoring of the chiller system can help identify and resolve high pressure issues before they cause significant damage.

• Examples...read more

TR Chiller machine is a type of chiller used for cooling applications in various industries.

• TR Chiller machine is a refrigeration system that removes heat from a process or space.

• It uses a compressor, condenser, expansion valve, and evaporator to cool the fluid or air.

• TR stands for Ton of Refrigeration, which is a unit of cooling capacity.

• TR Chiller machines are commonly used in HVAC systems, industrial processes, and commercial buildings.

• They can be powered by electricity, n...read more

The same problem in a machine that occurs repeatedly.

• One common problem is overheating due to insufficient cooling.

• Another common problem is a faulty sensor causing inaccurate readings.

• A recurring issue could be a clogged filter leading to reduced efficiency.

• Frequent breakdowns may be caused by worn-out or damaged components.

• Inconsistent power supply can also be a recurring problem in machines.

Environmental monitoring in aseptic areas involves regular testing for contaminants to ensure a sterile environment.

• Perform air sampling to check for viable and non-viable particles.

• Conduct surface monitoring to detect any microbial contamination.

• Analyze water samples for microbial growth.

• Set acceptance criteria based on regulatory guidelines and company standards.

• Different grades include Grade A, B, C, and D with varying levels of cleanliness.

• Acceptance criteria may include ...read more

Our company uses a shell and tube condenser.

• The condenser is designed to transfer heat from the steam to the cooling water.

• It consists of a bundle of tubes through which the steam flows and a shell surrounding the tubes through which the cooling water flows.

• The shell and tube condenser is commonly used in power plants and industrial processes.

• Our company's condenser is made of stainless steel for durability and corrosion resistance.

Priming in pump is the process of removing air from the pump and filling it with liquid to create suction and start the pumping action.

• Priming is necessary to ensure the pump is filled with liquid and there is no air trapped inside.

• It involves filling the pump casing and suction pipe with liquid before starting the pump.

• Priming can be done manually or automatically depending on the type of pump.

• Examples of priming methods include using a priming valve, a vacuum pump, or a foo...read more

The chiller gas leak test method involves pressurizing the chiller system with a gas and using a detector to identify any leaks.

• Pressurize the chiller system with a gas, such as nitrogen or helium.

• Use a gas detector to identify any leaks in the system.

• Inspect all connections, valves, and fittings for potential leaks.

• Perform a bubble test by applying a soapy solution to suspected leak areas and look for bubbles.

• Utilize an electronic leak detector for more accurate and sensitiv...read more

Bacterial endotoxin test is performed to ensure water and products are free from harmful endotoxins.

• Perform the test using Limulus Amebocyte Lysate (LAL) assay

• Acceptance criteria for water is typically <0.25 EU/ml

• Acceptance criteria for products varies depending on the type of product and its intended use

• Ensure proper controls are in place to validate the test results

Cooling towers are classified into two types: open circuit and closed circuit.

• Open circuit cooling towers: Water is exposed to the atmosphere and cooled through evaporation.

• Closed circuit cooling towers: Water is cooled indirectly through a heat exchanger.

• Examples of cooling towers: Crossflow cooling tower, counterflow cooling tower, induced draft cooling tower, forced draft cooling tower.

A cooling tower problem refers to an issue or malfunction in the cooling system of a facility, which can lead to inefficient cooling or equipment failure.

• Cooling tower problems can include issues with water quality, such as scaling or fouling, which can reduce heat transfer efficiency.

• Mechanical problems like pump failures or fan malfunctions can also cause cooling tower problems.

• Inadequate maintenance or improper operation can contribute to cooling tower problems.

• Examples of...read more

Woking process SOP is a set of instructions that outlines the steps to be followed for safe and efficient operation of the Woking process.

• Woking process SOP includes safety procedures, equipment operation guidelines, and troubleshooting steps.

• It ensures that the process is carried out consistently and efficiently.

• Examples of Woking process SOPs include those for chemical manufacturing, food processing, and wastewater treatment.

• Regular review and updates of the SOP are necessa...read more

Service time refers to the duration of time a machine is in operation.

• Service time is measured in hours or minutes depending on the machine.

• It is important to keep track of service time to ensure proper maintenance and avoid breakdowns.

• Regular maintenance can increase service time and prolong the life of the machine.

• For example, a generator may have a service time of 500 hours before it needs an oil change.

• Monitoring service time can also help identify when a machine needs to...read more

Performing pH and weighing calibration involves following specific procedures to ensure accuracy.

• For pH calibration, use buffer solutions of known pH values to calibrate the pH meter.

• For weighing calibration, use calibrated weights to check the accuracy of the balance.

• Follow the manufacturer's instructions for both pH meter and balance calibration.

• Regularly perform calibration checks to maintain accuracy.

• Document all calibration procedures and results for traceability.

• Train s...read more

We are using a variety of microbial cultures including bacteria, fungi, and yeast for different purposes.

• Bacteria cultures such as E. coli, Bacillus subtilis

• Fungi cultures like Aspergillus niger, Penicillium chrysogenum

• Yeast cultures such as Saccharomyces cerevisiae

Media can be made by combining specific ingredients in a sterile environment. Growth promotion test is used to ensure the media supports the growth of microorganisms.

• Media is made by combining ingredients like agar, peptones, and nutrients in a sterile environment.

• The ingredients are mixed, sterilized, poured into plates or tubes, and allowed to solidify.

• Growth promotion test is performed by inoculating the media with known microorganisms to ensure they grow as expected.

• If th...read more

Autoclave is a device used to sterilize equipment and supplies by subjecting them to high pressure saturated steam.

• Autoclave uses high pressure and high temperature steam to kill microorganisms on equipment and supplies.

• It is commonly used in medical and laboratory settings to sterilize instruments and tools.

• Autoclaves are essential for ensuring that equipment is free from harmful bacteria and viruses.

• Proper maintenance and monitoring of autoclaves are necessary to ensure eff...read more

Supply chain end to end refers to the entire process of sourcing, manufacturing, and delivering products to customers.

• Starts with sourcing raw materials or components

• Moves on to manufacturing or production

• Followed by distribution and logistics

• Ends with delivery to customers

• Involves coordination between suppliers, manufacturers, distributors, and retailers