10+ Quest Global Interview Questions and Answers

NMR values of aromatic rings are affected by electron withdrawing and donating groups.

• Electron withdrawing groups shift NMR values downfield (to higher ppm)

• Electron donating groups shift NMR values upfield (to lower ppm)

• Examples: Nitro group (downfield shift), Methoxy group (upfield shift)

Protection and deprotection of organic compounds involves temporarily modifying functional groups to prevent unwanted reactions.

• Protection involves adding a protecting group to mask a reactive functional group

• Deprotection involves removing the protecting group to reveal the original functional group

• Common protecting groups include Boc (tert-butyloxycarbonyl) and TBDMS (tert-butyldimethylsilyl)

• Examples: Boc protection of an amine group, TBDMS protection of a hydroxyl group

NMR and IR values are analytical techniques used to determine the structure of a compound.

• NMR (Nuclear Magnetic Resonance) spectroscopy provides information about the number and types of atoms in a molecule, as well as their connectivity.

• IR (Infrared) spectroscopy is used to identify functional groups present in a compound based on the absorption of infrared radiation.

• NMR values are reported in ppm (parts per million) and can indicate the chemical environment of different nuc...read more

Benzene can be converted to chlorobenzene through electrophilic aromatic substitution using chlorine gas and a catalyst.

• Use chlorine gas and a catalyst in the presence of benzene

• Electrophilic aromatic substitution mechanism is followed

• Chlorobenzene is formed as the final product

Paracetamol is a common pain reliever and fever reducer.

• Analgesic and antipyretic properties

• Works by inhibiting the production of prostaglandins in the brain

• Commonly used for headaches, muscle aches, and fever

• Available in various forms such as tablets, capsules, and syrups

Paracetamol synthesis involves the reaction of p-aminophenol with acetic anhydride.

• Reaction involves the acetylation of p-aminophenol with acetic anhydride.

• The intermediate formed is then hydrolyzed to form paracetamol.

• The reaction is typically carried out under acidic conditions.

• The final product is purified through recrystallization.

• Commonly used catalysts include sulfuric acid or hydrochloric acid.

Safety precautions during tech transfer

• Ensure proper training of personnel involved in tech transfer

• Perform risk assessments and implement appropriate control measures

• Ensure proper documentation and communication between parties involved

• Perform equipment and facility qualification before transfer

• Ensure compliance with regulatory requirements

• Perform validation of the transferred process

• Ensure proper handling and disposal of hazardous materials

• Perform regular audits and reviews...read more

Scale up calculations and technology transfer are crucial for successful process engineering.

• Scale up calculations involve determining the necessary adjustments to a process when increasing production scale.

• Technology transfer involves transferring a process from one location to another, or from one organization to another.

• Both require careful planning, testing, and documentation to ensure success.

• Factors to consider include equipment capabilities, raw material availability, ...read more

Pre-Onboarding: Offer acceptance, background check, paperwork. Post-Onboarding: Orientation, training, feedback.

• Pre-Onboarding: Send offer letter, conduct background check, complete paperwork

• Post-Onboarding: Conduct orientation, provide training, gather feedback

• Pre-Onboarding: Verify employment eligibility, set up payroll and benefits

• Post-Onboarding: Assign mentor, schedule check-ins, provide ongoing support

• Pre-Onboarding: Communicate company culture and values, set expectati...read more