Aurigene Pharmaceutical Services
Amul India Interview Questions and Answers
Q1. NMR values of aromatic ring and affects on them from electron withdrawing abd donating groups
NMR values of aromatic rings are affected by electron withdrawing and donating groups.
Electron withdrawing groups shift NMR values downfield (to higher ppm)
Electron donating groups shift NMR values upfield (to lower ppm)
Examples: Nitro group (downfield shift), Methoxy group (upfield shift)
Q2. Protection and deprotection of organic compounds
Protection and deprotection of organic compounds involves temporarily modifying functional groups to prevent unwanted reactions.
Protection involves adding a protecting group to mask a reactive functional group
Deprotection involves removing the protecting group to reveal the original functional group
Common protecting groups include Boc (tert-butyloxycarbonyl) and TBDMS (tert-butyldimethylsilyl)
Examples: Boc protection of an amine group, TBDMS protection of a hydroxyl group
Q3. Nmr and ir values for given compound
NMR and IR values are analytical techniques used to determine the structure of a compound.
NMR (Nuclear Magnetic Resonance) spectroscopy provides information about the number and types of atoms in a molecule, as well as their connectivity.
IR (Infrared) spectroscopy is used to identify functional groups present in a compound based on the absorption of infrared radiation.
NMR values are reported in ppm (parts per million) and can indicate the chemical environment of different nuc...read more
Q4. Conversion of benzene to chlorobenzene
Benzene can be converted to chlorobenzene through electrophilic aromatic substitution using chlorine gas and a catalyst.
Use chlorine gas and a catalyst in the presence of benzene
Electrophilic aromatic substitution mechanism is followed
Chlorobenzene is formed as the final product
Q5. Characterisation of paracetamol
Paracetamol is a common pain reliever and fever reducer.
Analgesic and antipyretic properties
Works by inhibiting the production of prostaglandins in the brain
Commonly used for headaches, muscle aches, and fever
Available in various forms such as tablets, capsules, and syrups
Q6. Synthesis of paracetamol
Paracetamol synthesis involves the reaction of p-aminophenol with acetic anhydride.
Reaction involves the acetylation of p-aminophenol with acetic anhydride.
The intermediate formed is then hydrolyzed to form paracetamol.
The reaction is typically carried out under acidic conditions.
The final product is purified through recrystallization.
Commonly used catalysts include sulfuric acid or hydrochloric acid.
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