Infosys Interview Questions and Answers

To start method development of unknown compound by HPLC for RS, one should consider various factors.

• Identify the properties of the compound such as polarity, solubility, and stability

• Choose the appropriate column and mobile phase based on the properties of the compound

• Optimize the chromatographic conditions by adjusting the flow rate, gradient, and temperature

• Validate the method by checking the specificity, linearity, accuracy, and precision

• Compare the retention time and peak...read more

If mass balance is not achieved in force degradation, investigate the cause and repeat the experiment.

• Check for any errors in the calculations or measurements.

• Verify the accuracy of the instruments used.

• Repeat the experiment to ensure the results are consistent.

• Investigate the possibility of degradation pathways that were not accounted for.

• Consult with colleagues or experts in the field for guidance.

• Document all steps taken to address the issue for future reference.

To reduce peak tailings and improve resolution, one can optimize the chromatographic conditions.

• Adjust the mobile phase composition and pH

• Optimize the column temperature and flow rate

• Use appropriate sample preparation techniques

• Consider using a different column or stationary phase

• Ensure proper calibration of the instrument

• Perform regular maintenance and cleaning of the equipment

QDA is a statistical method used for classification and prediction of data based on its attributes.

• QDA stands for Quadratic Discriminant Analysis.

• It is a supervised learning algorithm used in machine learning.

• It is based on Bayes' theorem and assumes that the data follows a Gaussian distribution.

• QDA calculates the probability of a data point belonging to a particular class based on its attributes.

• It then assigns the data point to the class with the highest probability.

• QDA is ...read more

The granulation department uses various types of equipment for the production process.

• High shear granulator

• Fluid bed granulator

• Roller compactor

• Mixer

• Dryer

• Sifter

• Mill

• Blender