Explain Method validation parameters

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Accepted Answer

Method validation parameters are criteria used to ensure that a method is reliable, accurate, and reproducible.

Parameters include accuracy, precision, specificity, linearity, range, limit of detection, limit of quantitation, robustness, and ruggedness.
Accuracy refers to how close the measured value is to the true value.
Precision is the degree of agreement between repeated measurements.
Specificity measures the ability of the method to differentiate the analyte from other components.
Linearity assesses the relationship between the analyte concentration and the response.
Range is the interval over which the method is accurate and precise.
Limit of detection is the lowest concentration of analyte that can be reliably detected.
Limit of quantitation is the lowest concentration of analyte that can be quantified with acceptable accuracy and precision.
Robustness evaluates the method's ability to remain unaffected by small variations in parameters.
Ruggedness assesses the method's performance under different conditions or by different analysts.

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