10+ Nagarjuna Construction Company Interview Questions and Answers

LOQ stands for Limit of Quantitation as per ICH guidelines. It is the lowest concentration of an analyte that can be reliably measured.

• LOQ is determined by analyzing a series of samples with known concentrations of the analyte and calculating the standard deviation and slope of the calibration curve.

• The LOQ is typically defined as the concentration at which the signal-to-noise ratio is at least 10:1.

• It is important to establish the LOQ for a method to ensure accurate and prec...read more

Specificity in assay method refers to the ability of the method to accurately measure only the target analyte without interference from other substances.

• Specificity is determined by testing the method with known standards and samples containing the target analyte as well as potential interfering substances.

• Cross-reactivity with similar compounds should be evaluated to ensure the method is specific to the target analyte.

• Selectivity is another term used interchangeably with spe...read more

The question asks for a reaction and prediction of H1 NMR under different conditions.

• Provide a detailed reaction involving a compound and reagent

• Discuss the possible H1 NMR shifts based on the reaction conditions

• Consider variations in temperature, solvent, and concentration for different predictions

Degradation studies are essential to understand the stability and shelf-life of pharmaceutical products.

• To determine the degradation pathways of a drug substance or product

• To establish the shelf-life of a pharmaceutical product

• To ensure the safety and efficacy of the product over time

• To comply with regulatory requirements

• To optimize storage conditions for the product

• Examples: conducting stress testing, accelerated stability studies, photostability testing

Chemical reactions involve the breaking and forming of chemical bonds to create new substances with different properties.

• Chemical reactions involve the rearrangement of atoms to form new substances

• Reactants are the starting materials and products are the end result of a chemical reaction

• Chemical reactions can be classified as exothermic or endothermic based on energy changes

• Catalysts can speed up chemical reactions without being consumed in the process

Solvent classes include polar, nonpolar, protic, aprotic, and supercritical fluids.

• Polar solvents dissolve polar compounds and have a dipole moment.

• Nonpolar solvents dissolve nonpolar compounds and lack a dipole moment.

• Protic solvents have a hydrogen atom attached to an electronegative atom and can donate hydrogen bonds.

• Aprotic solvents lack a hydrogen atom attached to an electronegative atom and cannot donate hydrogen bonds.

• Supercritical fluids have properties of both a gas ...read more

Solubility studies are conducted to determine the ability of a substance to dissolve in a particular solvent.

• Solubility studies involve testing the solubility of a substance in different solvents.

• Various methods such as shake flask method, equilibrium solubility method, and kinetic solubility method can be used.

• Factors affecting solubility include temperature, pH, and particle size.

• Analytical techniques like UV-Vis spectroscopy, HPLC, and LC-MS can be used to analyze solubili...read more

Mechanical calibration of Dissolution Apparatus involves ensuring the apparatus is functioning accurately and consistently.

• Calibration involves checking the alignment of the shaft, speed of rotation, temperature control, and vessel centering.

• Regular calibration is necessary to ensure accurate and reliable dissolution testing results.

• Examples of calibration methods include using standard weights for balance calibration and checking the rotation speed with a tachometer.

• Calibrat...read more

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