About clinical trail phases, blindhing, classification of oral hypoglycemics, parkinsons disease pathology and classification of drugs, about project, pharmacokinetics and formulas

Question

Accepted Answer

4 phases of Clinical trials : 1phase - for safety in man's, 2phase- for dosing regimen in patients , 3phase- for therapeutic efficacy , 4 phase- post market survivallence.

Blinding means the investigator and subjects unaware about the which treatement should be used for the trial.

Oral hypoglycemic:

PATHALOGY : type 1- pancreatic beta cells not able produce insulin

Type 2 - insulin not able to used by the body drugs:Biguanides - Metformin

Sulfonyl ureas- glibenclamide

Meglitinides- repaglinide

Alpha glucose inhibitors - actresses

Parkinsons:

PATHALOGY - decreasing levels of dopamine and increasing levels of acetylcholine leads to Parkinson

Class of drugs: Dopamine agonist & precursor - bromocriptine& levodopa

Anticholinergic- benzhexol, beztropine.

Dopamine facilitator- amantidine

MoA inhibitor- selegiline,

PAHRMACOKINETICS : studying of ADME process

About clinical trail phases, blindhing, classification of oral hypoglycemics, parkinsons disease pathology and classification of drugs, about project, pharmacokinetics and formulas

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