What is the difference between HPLC and GC ?

Question

Accepted Answer

HPLC and GC are both analytical techniques used in chemistry, but they differ in the type of samples they can analyze.

HPLC stands for High Performance Liquid Chromatography, while GC stands for Gas Chromatography.
HPLC is used for analyzing samples that are soluble in liquid, while GC is used for analyzing samples that can be vaporized.
HPLC uses a liquid mobile phase and a solid stationary phase, while GC uses a gas mobile phase and a solid or liquid stationary phase.
HPLC is more suitable for analyzing polar compounds, while GC is more suitable for analyzing non-polar compounds.
Examples of samples analyzed by HPLC include pharmaceutical drugs, amino acids, and pesticides, while examples for GC include volatile organic compounds, fatty acids, and environmental pollutants.

Accepted Answer

Gas chromatography

Gas is mobile phase ,column is stationary phase used to find different components of residual solvents

High performance liquid chromatography

Polar,non polar solutions used for mobile phase

Stainless steel non polar silica columns,polar chiral columns used for stationary phase to find different components their polar and non polar nature

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