13 SAI Life Sciences Jobs

Job Description and responsibilities:

• Experience in conducting the in vitro intrinsic clearance assays in liver microsomes, S9 fractions and other matrices
• This position requires experience in writing the scripts on liquid handlers and customise the assays based on the requirement
• Designing of microsomal stability, CYP inhibition, MBI and prediction of drug-drug interactions based on the in vitro data points
• Hands on experience in conducting the reaction phenotyping assays both the over expressed enzyme system and in the human liver microsomes
• Experience in UGT substrate and inhibition assays in the over expressed enzyme systems and in the human liver microsomes
• Coordination with cross functional teams (bioanalytical and discovery chemistry teams) to generate ADME end points
• Data compilation and knowledge on In-vitro to In-vivo extrapolation and fold induction change.
• Able to understand or read the data, identify data variability and data review cycle with QA team.
• This position includes commitment in delivering the data within the agreed timelines (5 days) and strong work ethics to complete the assigned jobs.
• Mentoring team members and development of new assay methodologies
• Building of regression models to build IVIVE
• Maintenance of inventory, lab infrastructure and working closely with team members
• Good oral/written communication skills..