Research Scientist - Analytical PRI

Role & responsibilities

Strategic

• Actively imbibing the values and philosophy of PI Industries.
• Efficient contribution to the overall success of product innovation (PRI) through scientific contribution to objectives and targets being set by the leadership team.
• Fullfilling requirements and achieveing goals set by the Team Leader and Group Leader
• Working as a team member, contributing to the team objective with special focus on achiving and exceeding the set target.
• Development of individual & team strengths by attending trainings based on the regular feedback as an individual and as a team

Operational

• Monitoring reaction masses using LCMS/GCMS.
• Execution of purity assessment and assay determination of samples using GC/HPLC/UFLC.
• Able to carry method development for challenging compounds through GC/GCMS/HPLC/UFLC
• Developing methods on Prep HPLC for purification/isolation of impure compounds.
• Elucidating and confirming structures using NMR, FTIR and LCMS/MS
• Ensure the scheduled performance of calibrations, Preventive maintenance and troubleshooting of core analytical instrument.
• Following the set instrument maintenance practices like periodic solvent changes, system flushing, etc.
• Assist the other team members in day to day activities like sample preparation, method developments, report generation and data management.
• Following safety practices with out fail.

Financial

• Planning the activities with existing resources and infra structure.
• Suggesting the cost-effective areas to the Team Leader / Group Leader
• Developing methods to improve the environment safety and to reduce the cost.

People

• Collaborate with team members and cross functional teams to meet research objectives.
• Develop and foster positive relationships with other teams and support groups to maximize cooperation and consequent benefit to objective delivery
• Should be able to work in multitasking environment
• Ensure team harmony through collaboration and active participation in all team discussion

Apart from the above responibilities, specific responsibilities of Research scientists

Note : The Associate would in any of the areas listed below based on the requirement and should have sufficient knowledge and expertise in the area alloted as listed below

1. HPLC/UFLC

• Candidate should be well versed with normal and reverse phase chromatography techniques.
• Able to optimize chromatographic methods
• Keen knowledge on low level analyte-impurities quantification by HPLC.

2. LCMS SQD & TQD

• Well versed with operations of one or more makes of LCMS-SQD & TQD instruments.
• Aware of basic principles related to mass spectrometry, sources, analysers and detectors.
• Hands on experience in analysis of compounds using LCMS instrument and releasing the mass confirmation reports.
• Keen knowledge on ppb / ppm level quantification of analytes from AI, formulations, various matrices like microsomes, soil, plant extracts by LCMSMS.
• Perform possible structural elucidation/Identification of degradants/metabolites/impurities using LCMS/MS

3. NMR

• Perform suitable 1D/2D NMR experiments based on the requirement and confirm one among proposed structures or propose a new structure.
• Manage the NMR activities viz, perform routine NMR (1D&2D) analysis, QNMR, cryogen replenishing.
• Keen knowledge of NMR technology & instrument maintenance.

4. Physchem assays

• Have hands on knowledge of various in vitro ADME/ physchem assays like solubility, LogP, pKa and in vitro Metabolic stability assay.
• Able to develop methods, check method compatibility for accuracy, precision, matrix effect and apply it further for the quantification of formulations, plant extracts, various matrices like soil, microsomes etc.
• Perform the microsomal stability experiments to determine half-life and Clint. Awareness about Met ID using various scans, fragmentation tree & HRMS will be an added advantage.
• Knowledge about sample preparation and analysis of photo stability and hydrolytic stability.

5. Prep-HPLC

• Able to develop a robust chromatographic method both at analytical and preparative scale, by designing cost effective methods for chiral and achiral molecules.
• Knowledge of chiral chromatography and isolation of enantiomers using preparative HPLC

Preferred candidate profile

• MSc/ Pharm/PhD in Analytical Chemistry/ Agro Chemistry/Organic chemistry from a reputed University / Institute with excellent academic credentials.
• Research publications and/or patents appreciated
• 2-10 years of hands on experience on GC / GCMS / HPLC / UFLC / LCMS / NMR / Prep-HPLC instrument

Interested candidates may share profiles on shubhi.chandnani@piind.com and can reach out on 8875001305