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246 Novartis Jobs
Senior Principal Data Scientist, CADD
5-10 years
Hyderabad / Secunderabad
1 vacancy
Senior Principal Data Scientist, CADD
Novartis
posted 2mon ago
Job Role Insights
Flexible timing
Key skills for the job
Job Description
- Drive the design of medicinal chemistry efforts by applying in-depth knowledge of structure-activity relationships (SAR), a profound understanding of target biology, and predictive methods for assessing on- and off-target activity, physical properties, pharmacokinetics / pharmacodynamics (PK/PD), and synthetic feasibility.
- Thrive at the intersection of experimental and groundbreaking digital technologies, with a particular emphasis on expertise in machine learning and artificial intelligence (AI) as applied to small molecule drug discovery.
- Stay abreast of scientific literature and engage with internal and external scientists to incorporate biological insights into lead characterization and screening initiatives.
- Collaborate with interdisciplinary project teams to facilitate effective decision-making throughout the target identification to candidate nomination process. This involves applying and developing predictive models based on high-content and time-resolved screening data, including imaging techniques.
- Drive hypothesis generation to enhance clinical success rates for programs involving small molecules, peptides, RNAs, protein degradation, molecular glues, transient covalent inhibitors, and kinetic stabilization of drug-target complexes.
- Take a leading role in cross-disciplinary mechanistic studies using physics-based modeling and simulation, biophysical characterization, and cellular validation. These studies will inform the strategic targeting strategies of discovery projects, aiming for optimal mechanisms of action (MoAs).
Minimum Requirements:
- Advanced degree in medicinal chemistry, computational chemistry, computational biology, computational chemical biology, or a related field. Candidates with a laboratory-based background in chemistry and biology, supplemented with strong computational experience, are also encouraged to apply.
- 5+ years of experience working with project teams in a drug discovery environment.
- Proven track record of innovation through analogue design, leading to significant impact on discovery projects.
- Familiarity with drug design tools and high-performance computing environments and strong publication history in peer-reviewed journals.
Skills and Abilities:
- Proactively anticipates project needs with a clinical focus.
- Demonstrates rigor and diligence in idea substantiation, analogue design, and experimentation.
- Strong team orientation with multitasking and adaptability in support and leadership roles.
- Effective listener with excellent written and oral communication skills.
- Proficient in data visualization to effectively communicate insights.
Employment Type: Full Time, Permanent
Read full job descriptionPrepare for Principal Data Scientist roles with real interview advice
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What people at Novartis are saying
Principal Data Scientist salary at Novartis
reported by
1
employee
with 13
years exp.
₹20.7
L/yr - ₹26.4
L/yr
53%
less
than the average Principal Data Scientist Salary in India
View more details
What Novartis employees are saying about work life
based on 1.6k employees
Flexible timing
Monday to Friday
No travel
Day Shift
Novartis Benefits
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